Polymer Microneedle Sensor
CMOS technology has many advantages when applied to sensors. CMOS sensors exhibit low power consumption due to operation at low voltage levels, making them ideal for power-saving applications and battery-operated equipment. CMOS sensors can be easily integrated with other technologies and functions, such as microfluidics, optics or MEMS, enabling the development of advanced sensing systems with multiple functions. Measuring glucose concentration using a sensor relies on the principle of an enzymatic reaction. The sensor measures the electrical signal or change in current or potential caused by the oxidation reaction, which is directly proportional to the concentration of glucose in the sample. By calibrating the sensor with a known glucose concentration, a relationship between the electrical signal and glucose concentration can be established, enabling accurate measurements of glucose concentration in various samples.
Nanowire growth mechanism
In our group, Bio-modified electrode fabricate by SAMs(Self Assembled Monolayers) on the electrode surface, at which the aptamer that has specific affinity for the disease marker can be immobilized through the introduction of a functional group. We aim for POCT(Point-Of-Care Test) that can maker early diagnosis through electrochemical analysis(EX : Nyquist plot, Bode plot) by charge transfer reaction on the electrode between marker-aptamer.
03 Neural probe
Neural probe modification
To control the properties of neural probe, the electrode is modified by different materials. The materials are coated by CVD, electro-deposition, dip coating as their usage. Using the neural probe, we can record signal from nerves and stimulate to the target point. For recording gold, platinum, carbon materials (graphene, graphite) are coated to reduce the impedance and increase the bio-compatibilty. For stimulating the materials with high capacitance or low resistance are coated to reduce the impedance and increase the stabiltiy.
This project aims to enhance cognitive functions in humans by stimulating the hippocampus, a deep region of the brain, using various nanoparticles. The hippocampus is a critical area associated with memory formation, and by stimulating it, we aim to improve learning abilities, memory retention, information processing speed, and other cognitive functions.
We are synthesizing a diverse range of nanoparticles based on ferrite for this project. These nanoparticles have various characteristics such as size, shape, and composition, and they possess the ability to effectively stimulate specific neural circuits within the hippocampus. The synthesis of these nanoparticles is carried out using advanced materials science technology and chemical synthesis methods, with the goal of developing nanoparticles with optimal performance while considering safety and efficiency.
In addition, this project utilizes computer simulations to overcome the limitations of magnetogenetics, specifically the challenge of multi-channel stimulation. Through computer simulations, we calculate and analyze the magnetic properties and stimulation efficiency of nanoparticles under various stimulation conditions. Based on these calculations, we aim to fabricate nanoparticles and apply them to the hippocampus, resulting in precise and effective enhancement of cognitive functions.
Furthermore, this project has long-term objectives in contributing to the development of nanoparticle technology, which could have positive implications for the treatment and rehabilitation of various neurological disorders. The development of sophisticated brain stimulation techniques using nanoparticles offers new possibilities for addressing neurological conditions that are difficult to treat with traditional methods or medication.